20. Juni 2022

Leberschäden bei Kindern als Folge einer Covid-19-Infektion?

Die Ursache für die rätselhafte Häufung von Hepatitisfällen bei Kindern ist nach wie vor unklar. Eine kleine Fallstudie suggeriert nun einen Zusammenhang mit einer Covid-19-Infektion. Externe Forschende betonen zwar die Limitationen der Untersuchung, geben aber keine Entwarnung.1-13

Lesedauer: ca. 9 Minuten

Redaktion: Marie Fahrenhold

Zusammenhang mit Covid-19-Erkrankung bisher nicht bestätigt

Mitte Februar meldeten die britischen Gesundheitsbehörden erstmals eine ungewöhnliche Häufung von Hepatitisfällen bei Kindern. Seitdem sind mehrere solcher Fälle in verschiedenen Ländern aufgetreten – teils auch schon früher, wie man rückblickend nun weiß. Bis zum 09.06.2022 wurden gut 400 Fälle von akuter Hepatitis unbekannter Ätiologie bei Kindern im Alter von 16 Jahren und darunter aus der europäischen Region gemeldet 1.

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Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Massive Nekrose und Wucherungen in den Gallenwegen

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Studienautoren sprechen von „Long Covid-19 Liver Manifestation“

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

3 Expertenstatements

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Prof. Dr. Ansgar Lohse
Klinikdirektor, Facharzt für Innere Medizin und Gastroenterologie, Universitätsklinikum Hamburg-Eppendorf

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Prof. Dr. Sandra Ciesek
Direktorin des Instituts für medizinische Virologie, Universitätsklinikum Frankfurt

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Prof. Dr. Bertram Bengsch
Leiter der Arbeitsgruppe "Translationale Systemimmunologie in der Hepatogastroenterologie", Klinik für Innere Medizin II, Universitätsklinikum Freiburg

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

Teachers, bodies, and prime spirits will always protect them.Est neuter glos, cesaris.Bourbon soup is just not the same without garlic and chopped salted onions.

1. European Centre for Disease Prevention and Control (10.06.2022): Hepatitis of Unknown Origin in Children. Surveillance Bulletin.

2. Brodin P et al. (2022): Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens. The Lancet Gastroenterology and Hepatology. DOI: 10.1016/S2468-1253(22)00166-2.

3. Cooper S et al. Long COVID-19 Liver Manifestation in ChildrenJ Pediatr Gastroenterol Nutr . 2022. doi: 10.1097/MPG.0000000000003521

4. Rojas M et al. (2021): Cholangiopathy as part of post-COVID syndrome. Journal of Translational Autoimmunity. DOI: 10.1016/j.jtauto.2021.10011

5. Xiaoqiang C et al. (2020): Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection. Biorxiv. DOI: 10.1101/2020.02.03.931766. (Noch nicht begutachtetes Preprint)

6. Zhang H et al. (2020): Digestive system is a potential route of COVID-19: an analysis of single-cell coexpression pattern of key proteins in viral entry process. Gut. DOI: 10.1136/gutjnl-2020-321195.

7. Kleine R et al. (2022): Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022. Eurosurveillance. DOI: 10.2807/1560-7917.ES.2022.27.19.2200369.

8. Brisca G et al. (2021): SARS-CoV-2 Infection May Present as Acute Hepatitis in Children. The Pediatric Infectious Disease Journal. DOI: 10.1097/INF.0000000000003098.

9. Draganescu AC et al. (2021): Transient immune hepatitis as post-coronavirus disease complication: A case report. World Journal of Clinical Cases. DOI: 10.12998/wjcc.v9.i16.4032.

10. Russo FP et al. (2022): COVID-19 and liver disease: where are we now? Nature Reviews Gastroenterology & Hepatology. DOI: 10.1038/s41575-022-00607

11. Wanner N et al. (2022): Molecular consequences of SARS-CoV-2 liver tropism. Nature Metabolism. DOI: 10.1038/s42255-022-00552-6.

12. Polkas NK et al. (2006): Kupffer cell-dependent hepatitis occurs during influenza infection. The American Journal of Pathology. DOI: 10.2353/ajpath.2006.050875.

13. Science Media Center, Leberschäden bei Kindern als Folge von COVID-19?, 15.6.2022

 

Bildquelle: (c) Getty Images / Cavan Images (Symbolbild mit Fotomodell)

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